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Characterization of multivalent lactose quantum dots and its application in carbohydrate-protein interactions study and cell imaging

        We have previously reported a facile and convenient method for the preparation of a new type of lactose-CdSeS/ZnS quantum dots conjugates (Lac-QDs) that exhibit biocompatibility, noncytotoxicity and specificity to leukocytes. In order to further study the carbohydrate-protein interactions, a series of Lac-QDs with different lactose densities and a PEGylated (n=3) lactose-QDs conjugate (LacPEG-QDs) with more flexible sugar ligands were prepared. The amount of the sugar molecules on QDs can be determined by NMR, which was in agreement with the results from TGA determination. The formula of the conjugates was determined with ICP-OES. The interactions between..........The fabrication of lactose on QDs provides a fluorescent multivalent carbohydrate probe that can be used as mimics of glycoprotein for the study of carbohydrate-protein interactions and cell imaging.

  • 合金型量子点获得国家知识产权局的专利授权(ZL 200610163308.3)

  • 实验室欢迎约翰-霍普金斯大学的Janice Lin做短期合作研究。

  • 喻敏、刘莹、贺晓辉和隗明同学完成学业,并通过学位论文答辩。

  • Bioorg.Med.Chem在线刊登杨杨与喻敏关于寡糖量子点探针的研究论文。

Yang Yang, Min Yu, et-al. Bioorganic & Medicinal Chemistry. (in press, 2010)

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  纳米生物学以多学科交叉为特点,需要不同学科的合作与交流。与合作伙伴的密切协作,决定了......

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  量子点探针以出色的光谱质量、特征的表面化学结构和优异的生物分子缀合能力,在分子、活细胞......

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